Colesevelam Hcl (Welchol)- FDA

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Levy To Raise A Boy: Classrooms, Locker Rooms, Bedrooms, and the Hidden Struggles of American Boyhood Emma Brown Single On Purpose: Redefine Everything. Brahma Department of Pharmacology NEIGRIHMS, Shillong how the human body act. What is Pharmacokinetics how the human body act on the drugs. Pharmacokinetics is Colesevelam Hcl (Welchol)- FDA quantitative Colesevelam Hcl (Welchol)- FDA of drug movement in, through and out of the body. Intensity of effect is related Colesevelam Hcl (Welchol)- FDA concentration of the drug at the site of action, which depends on its pharmacokinetic properties Pharmacokinetic properties of particular drug is important to determine the route of administration, dose, onset of action, peak action influenza, duration of action and frequency of dosing 3.

The Pharmacokinetic Process 5. The Pharmacokinetic Process 6. Biological Membrane - image Drug molecules can cross cell m. Passive transport (down hill movement) Most important Mechanism for most of the Drugs Majority of drugs diffuses across the membrane in the direction of concentration gradient No active role of the membrane Proportional to lipid : water partition coefficient Lipid soluble drugs diffuse by dissolving in the lipoidal matrix of the membrane Characteristics Not requiring energy Having no saturation Having no carriers Not resisting competitive inhibition Affecting factors : 9.

Passive transport Colesevelam Hcl (Welchol)- FDA factors : the size of molecule lipid solubility polarity degree of ionization the PH of the environment such as: fluid of body fluid in cell blood, urine The drugs which are Unionized, low polarit.

Remember The drugs which are Unionized, low polarity and higher lipid solubility are easy to permeate membrane. The drugs which are ionized, high polarity and lower lipid solubility are difficult to permeate membrane. Most of drugs are weak acids or weak base. The ionization of drugs may Colesevelam Hcl (Welchol)- FDA reduce their ability to permeate membranes. The degree of ionization of drugs is determined by the surrounding pH and their pKa. Filtration Involve specific membran.

Specific, saturable and inhibitable Depending on Energy requirement Colesevelam Hcl (Welchol)- FDA Can be either Facilitated (passive) or Active Transport Move substrate of a singl.

Facilitative transporters Move substrate of a single class (uniporters) down a concentration gradient No energy dependent Similar to entry of glucose into muscle (GLUT 4) Active (concen. ATP hydrolysis) Secondary transporters - utilize energy stored in voltage and ion gradients generated by a primary active transporter (e. Pinocytosis It involves the invagination of a part of the cell membrane and trapping within the cell of a small vesicle containing extra cellular constituents.

Eiglustat Capsules (Cerdelga)- FDA vesicle contents can than be released within the cell, or extruded from the other side of the cell. Pinocytosis is important for the transport of some macromolecules (e.

Absorption is the transfer o. Absorption of Drugs Absorption is the transfer of a drug from its site of administration to the blood stream Most of drugs are absorbed by the way of passive transport Intravenous administration has no absorption Fraction of administered dose and rate Colesevelam Hcl (Welchol)- FDA absorption are important Drug properties:.

Factors affecting absorption Drug properties: lipid solubility, molecular weight, and polarity etc Blood flow to the absorption site Total surface area Colesevelam Hcl (Welchol)- FDA for absorption Contact time at the absorption surface Affinity with Colesevelam Hcl (Welchol)- FDA tissue Routes of Administration (important): Route of admi.

As a Result, the concentration of drug in the systemic circulation will be reduced. Bioavailability Bioavailability refers to the rate and extent Colesevelam Hcl (Welchol)- FDA absorption of a drug from dosage form as determined by Colesevelam Hcl (Welchol)- FDA concentration-time curve in blood or by its excretion in urine.

It is a measure of the fraction (F) of administered dose of a drug that reaches the systemic circulation in the unchanged form Bioavailability of drug injected i. MTC MEC It is the passage of drug.

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